[Future Therapeutic Targets in Management of Autoimmune Skin Diseases].
نویسندگان
چکیده
Pemphigus is a severe, potentially fatal bullous skin disease, caused by desmoglein autoantibody production and immune-mediated regulation of T-cells subsets. Conventional therapy including systemic corticosteroids with or without other immunosupressants causes numerous adverse effects and becomes inefficient in refractory patients. In this work, the authors showed a modern view on the pathogenesis ofpemphigus. This article describes the detailed action mechanism of rituximab, a chimeric monoclonal antibody directed against CD20 antigen of B-cells. The authors conduct the results of meta-analyses of rituximab's efficiency in pemphigus patients. Moreover, in this article, the authors consider new promising treatment tions and potential targets for biological therapy of pemphigus diseases.
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ورودعنوان ژورنال:
- Vestnik Rossiiskoi akademii meditsinskikh nauk
دوره 2 شماره
صفحات -
تاریخ انتشار 2015